Will Spooren : rechercher sur Z-Library

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1

Different Outcomes of the Wilcoxon-Mann-Whitney Test from Different Statistics Packages

Reinhard Bergmann, John Ludbrook and Will P. J. M. Spooren

Journal:

The American Statistician

Année:

2000

Langue:

english

Fichier:

PDF, 934 KB

english, 2000

2

New treatment targets for autism spectrum disorders: EU-AIMS

Loth, Eva, Spooren, Will, Murphy, Declan G

Journal:

The Lancet Psychiatry

Année:

2014

Langue:

english

Fichier:

PDF, 175 KB

english, 2014

3

Identification and validation of biomarkers for autism spectrum disorders

Loth, Eva, Spooren, Will, Ham, Lindsay M., Isaac, Maria B., Auriche-Benichou, Caroline, Banaschewski, Tobias, Baron-Cohen, Simon, Broich, Karl, Bölte, Sven, Bourgeron, Thomas, Charman, Tony, Collier,

Journal:

Nature Reviews Drug Discovery

Année:

2015

Langue:

english

Fichier:

PDF, 277 KB

english, 2015

4

Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands

Jens-Uwe Peters, Torsten Hoffmann, Patrick Schnider, Heinz Stadler, Andreas Koblet, André Alker, Sonia Maria Poli, Theresa M. Ballard, Will Spooren, Lucinda Steward, Andrew J. Sleight

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2010

5

Opinion: NK3 receptor antagonists: the next generation of antipsychotics?

Spooren, Will, Riemer, Claus, Meltzer, Herbert

Journal:

Nature Reviews Drug Discovery

Année:

2005

Langue:

english

Fichier:

PDF, 761 KB

english, 2005

6

Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversion

Carla Bills, Todd R. Schachtman, Peter Serfozo, Will P.J.M. Spooren, Fabrizio Gasparini, Agnes Simonyi

Journal:

Behavioural Brain Research

Année:

2005

Langue:

english

Fichier:

PDF, 147 KB

english, 2005

7

Different Outcomes of the Wilcoxon—Mann—Whitney Test from Different Statistics Packages

Bergmann, Reinhard, Ludbrook, John, Spooren, Will P. J. M.

Journal:

The American Statistician

Année:

2000

Langue:

english

Fichier:

PDF, 732 KB

english, 2000

8

EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort

Isaksson, Johan, Tammimies, Kristiina, Neufeld, Janina, Cauvet, Élodie, Lundin, Karl, Buitelaar, Jan K., Loth, Eva, Murphy, Declan G. M., Spooren, Will, Bölte, Sven

Journal:

Molecular Autism

Année:

2018

Langue:

english

Fichier:

PDF, 549 KB

english, 2018

9

Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

Horder, Jamie, Petrinovic, Marija M., Mendez, Maria A., Bruns, Andreas, Takumi, Toru, Spooren, Will, Barker, Gareth J., Künnecke, Basil, Murphy, Declan G.

Journal:

Translational Psychiatry

Année:

2018

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2018

10

Defining Precision Medicine Approaches to Autism Spectrum Disorders: Concepts and Challenges

Loth, Eva, Murphy, Declan G., Spooren, Will

Journal:

Frontiers in Psychiatry

Année:

2016

Langue:

english

Fichier:

PDF, 650 KB

english, 2016

11

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Bernd Büttelmann, Jens-Uwe Peters, Simona Ceccarelli, Sabine Kolczewski, Eric Vieira, Eric P. Prinssen, Will Spooren, Franz Schuler, Jörg Huwyler, Richard H.P. Porter, Georg Jaeschke

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 170 KB

english, 2006

12

Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure

Simona M. Ceccarelli, Georg Jaeschke, Bernd Buettelmann, Jörg Huwyler, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Richard Porter, Will Spooren, Eric Vieira

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 172 KB

english, 2007

13

Descending efferent connections of the sub-pallidal areas in the cat: Projections to the subthalamic nucleus, the hypothalamus, and the midbrain

Will P. J. M. Spooren, Jan G. Veening, Alexander R. Cools

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 5.51 MB

english, 1993

14

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition

Will Spooren, Cedric Mombereau, Martine Maco, Rammy Gill, John A. Kemp, Laurence Ozmen, Shigetada Nakanishi, Guy A. Higgins

Journal:

Psychopharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 229 KB

english, 2004

15

The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison

Theresa M. Ballard, Marie L. Woolley, Eric Prinssen, Jörg Huwyler, Richard Porter, Will Spooren

Journal:

Psychopharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 227 KB

english, 2005

16

Contingent negative variation as a dopaminergic biomarker: evidence from dose-related effects of methylphenidate

Anke M. W. Linssen, Eric F. P. M. Vuurman, Anke Sambeth, Stephane Nave, Will Spooren, Gabriel Vargas, Luca Santarelli, Wim J. Riedel

Journal:

Psychopharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 276 KB

english, 2011

17

Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes

Kahle, Philipp J., Neumann, Manuela, Ozmen, Laurence, Müller, Veronika, Jacobsen, Helmut, Spooren, Will, Fuss, Babette, Mallon, Barbara, Macklin, Wendy B., Fujiwara, Hideo

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 416 KB

english, 2002

18

Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair

Goeldner, Celia, Spooren, Will, Wichmann, Jürgen, Prinssen, Eric P.

Journal:

Psychopharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 482 KB

english, 2012

19

Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP

Rebecca E. Nordquist, Sean Durkin, Georg Jaeschke, Will Spooren

Journal:

European Journal of Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 142 KB

english, 2007

20

The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils

Rebecca E. Nordquist, Sean Durkin, Aurélie Jacquet, Will Spooren

Journal:

European Journal of Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 394 KB

english, 2008

21

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

Will P.J.M Spooren, Fabrizio Gasparini, Herman van der Putten, Manuel Koller, Shigetada Nakanishi, Rainer Kuhn

Journal:

European Journal of Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 79 KB

english, 2000

22

Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

Will P.J.M Spooren, Fabrizio Gasparini, Reinhard Bergmann, Rainer Kuhn

Journal:

European Journal of Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 202 KB

english, 2000

23

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608)

Will P.J.M Spooren, Philippe Schoeffter, Fabrizio Gasparini, Rainer Kuhn, Conrad Gentsch

Journal:

European Journal of Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 250 KB

english, 2002

24

Differences in pre- and post-synaptic sensitivity to apomorphine between saline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57BL/6 mice as reflected in climbing activity

Will P.J.M Spooren, Annick Vassout, Peter Waldmeier, Conrad Gentsch

Journal:

European Journal of Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 102 KB

english, 1998

25

Dopamine D1 receptors in the sub-commissural part of the globus pallidus and their role in oro-facial dyskinesia in cats

Will P.J.M. Spooren, Petra A. Piosik, Alexander R. Cools

Journal:

European Journal of Pharmacology

Année:

1991

Langue:

english

Fichier:

PDF, 683 KB

english, 1991

26

Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice

Christian Freichel, Manuela Neumann, Theresa Ballard, Veronika Müller, Marie Woolley, Laurence Ozmen, Edilio Borroni, Hans A. Kretzschmar, Christian Haass, Will Spooren, Philipp J. Kahle

Journal:

Neurobiology of Aging

Année:

2007

Langue:

english

Fichier:

PDF, 1.71 MB

english, 2007

27

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

Aubin Michalon, Michael Sidorov, Theresa M. Ballard, Laurence Ozmen, Will Spooren, Joseph G. Wettstein, Georg Jaeschke, Mark F. Bear, Lothar Lindemann

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 905 KB

english, 2012

28

Pharmacological characterization of senktide-induced tail whips

Rebecca E. Nordquist, Theresa M. Ballard, Brigitte Algeyer, Meike Pauly-Evers, Laurence Ozmen, Will Spooren

Journal:

Neuropharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 712 KB

english, 2010

29

Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

Will P.J.M. Spooren, Fabrizio Gasparini, Thomas E. Salt, Rainer Kuhn

Journal:

Trends in Pharmacological Sciences

Année:

2001

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2001

30

Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1)

Valérie Schuler, Christian Lüscher, Christophe Blanchet, Norman Klix, Gilles Sansig, Klaus Klebs, Markus Schmutz, Jakob Heid, Clive Gentry, Laszlo Urban, Alyson Fox, Will Spooren, Anne-Lise Jaton, Jea

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 486 KB

english, 2001

31

CHARACTERIZATION OF RO4583298 AS A HIGHLY POTENT, DUAL ANTAGONIST WITH IN VIVO ACTIVITY AT TACHYKININ NK1 AND NK3 RECEPTORS

Pari Malherbe, Frédéric Knoflach, Lucinda Steward, Maria-Clemencia Hernandez, Torsten Hoffmann, Patrick Schnider, Richard H. Porter, Theresa M. Ballard, Will Spooren

Journal:

Schizophrenia Research

Année:

2010

Langue:

english

Fichier:

PDF, 90 KB

english, 2010

32

Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders

Will Spooren, Lothar Lindemann, Anirvan Ghosh, Luca Santarelli

Journal:

Trends in Pharmacological Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2012

33

MAPPING THE BINDING SITE FOR TACHYKININ NK3 RECEPTOR ANTAGONISTS

Pari Malherbe, Caterina Bissantz, Frédéric Knoflach, Maria-Clemencia Hernandez, Lucinda Steward, Anne Marcuz, Claudia Kratzeisen, Marie-Thérèse Zenner, Hasane Ratni, Claus Riemer, Will Spooren, Joseph

Journal:

Schizophrenia Research

Année:

2008

Langue:

english

Fichier:

PDF, 61 KB

english, 2008

34

CLONING AND PHARMACOLOGICAL PROFILE OF THE GERBIL (MERIONESUNGUICULATUS) NK3 RECEPTOR: COMPARISON WITH HUMAN, RAT ANDMOUSE NK3 RECEPTORS

Lucinda Steward, Richard Porter, Will Spooren, Joseph Wettstein, Maria-Clemencia Hernandez

Journal:

Schizophrenia Research

Année:

2008

Langue:

english

Fichier:

PDF, 62 KB

english, 2008

35

Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice

Amber R Salomons, Nathaly Espitia Pinzon, Hetty Boleij, Susanne Kirchhoff, Saskia S Arndt, Rebecca E Nordquist, Lothar Lindemann, Georg Jaeschke, Will Spooren, Frauke Ohl

Journal:

Behavioral and Brain Functions

Année:

2012

Langue:

english

Fichier:

PDF, 449 KB

english, 2012

36

Using genetic findings in autism for the development of new pharmaceutical compounds

Vorstman, Jacob A. S., Spooren, Will, Persico, Antonio M., Collier, David A., Aigner, Stefan, Jagasia, Ravi, Glennon, Jeffrey C., Buitelaar, Jan K.

Journal:

Psychopharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 423 KB

english, 2014

37

Autism spectrum disorders - an emerging area in psychopharmacology

Steckler, Thomas, Spooren, Will, Murphy, Declan

Journal:

Psychopharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 85 KB

english, 2014

38

Alexander Rudolf Cools (1942–2013)

Ellenbroek, Bart A., Homberg, Judith, Verheij, Michel, Spooren, Will, van den Bos, Ruud, Martens, Gerard

Journal:

Psychopharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 131 KB

english, 2014

39

Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: Biochemical and electrophysiological characterization

Malherbe, Pari, Knoflach, Frédéric, Marcuz, Anne, Bohnert, Claudia, Weber, Michael, Knust, Henner, Ratni, Hasane, Spooren, Will, Ballard, Theresa M., Bissantz, Caterina

Journal:

Neuropharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2014

40

Public-Private Partnership: A New Engine for Translational Research in Neurosciences

Murphy, Declan G.M., Goldman, Michel, Loth, Eva, Spooren, Will

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 438 KB

english, 2014

41

European clinical network: autism spectrum disorder assessments and patient characterisation

Ashwood, Karen L., Buitelaar, Jan, Murphy, Declan, Spooren, Will, Charman, Tony

Journal:

European Child & Adolescent Psychiatry

Année:

2015

Langue:

english

Fichier:

PDF, 741 KB

english, 2015

42

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1 H -imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk,

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2015

43

mGlu5 receptor antagonists and their therapeutic potential

Jaeschke, Georg, Wettstein, Joseph G, Nordquist, Rebecca E, Spooren, Will

Journal:

Expert Opinion on Therapeutic Patents

Année:

2008

Langue:

english

Fichier:

PDF, 581 KB

english, 2008

44

EU-AIMS: a boost to autism research

Murphy, Declan, Spooren, Will

Journal:

Nature Reviews Drug Discovery

Année:

2012

Langue:

english

Fichier:

PDF, 104 KB

english, 2012

45

Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity

Saenger, Stefanie, Holtmann, Bettina, Nilges, Mark R., Schroeder, Susanne, Hoeflich, Andreas, Kletzl, Heidemarie, Spooren, Will, Ostrowitzki, Susanne, Hanania, Taleen, Sendtner, Michael, Metzger, Frie

Journal:

Amyotrophic Lateral Sclerosis

Année:

2012

Langue:

english

Fichier:

PDF, 415 KB

english, 2012

46

Descending efferent connections of the sub-pallidal areas in the cat: projections to the lateral habenula

Spooren, Will P. J. M., Haber, Suzanne N., Veening, Jan G., Cools, Alexander R.

Journal:

Année:

1995

Fichier:

PDF, 237 KB

1995

47

Comprehensive Analysis of Two Shank3 and the Cacna1c Mouse Models of Autism Spectrum Disorder

Kabitzke, Patricia, Brunner, Daniela, He, Dansha, Fazio, Pamela A., Cox, Kimberly, Sutphen, Jane, Thiede, Lucinda, Sabath, Emily, Hanania, Taleen, Alexandrov, Vadim, Rasmusson, Randall, Spooren, Will,

Journal:

Genes, Brain and Behavior

Année:

2017

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2017

48

Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism

Breysse, Nathalie, Baunez, Christelle, Spooren, Will, Gasparini, Fabrizio, Amalric, Marianne

Journal:

Journal of Neuroscience

Année:

2002

Langue:

english

Fichier:

PDF, 362 KB

english, 2002

49

Neuroimaging, Genetics, and Clinical Data Sharing in Python Using the CubicWeb Framework

Grigis, Antoine, Goyard, David, Cherbonnier, Robin, Gareau, Thomas, Papadopoulos Orfanos, Dimitri, Chauvat, Nicolas, Di Mascio, Adrien, Schumann, Gunter, Spooren, Will, Murphy, Declan, Frouin, Vincent

Journal:

Frontiers in Neuroinformatics

Année:

2017

Langue:

english

Fichier:

PDF, 2.62 MB

english, 2017

50

Early and Selective Loss of Neuromuscular Synapse Subtypes with Low Sprouting Competence in Motoneuron Diseases

Frey, Dunja, Schneider, Corinna, Xu, Lan, Borg, Jacques, Spooren, Will, Caroni, Pico

Journal:

Journal of Neuroscience

Année:

2000

Langue:

english

Fichier:

PDF, 1001 KB

english, 2000